Researchers innovate an efficient method for extended drug administration
MIT researchers have developed a novel method for administering certain drugs in higher concentrations with less pain, using suspensions of minuscule crystals. This innovative approach allows for the formation of a drug "depot" under the skin, which could potentially last for years, thereby eliminating the need for frequent drug injections.
This development could be particularly beneficial for delivering long-lasting contraceptives or drugs that require prolonged usage. The drugs, suspended in a solution, can be injected through a thin needle, which is easier for patients to tolerate due to its narrow size.
The efficacy of the tiny crystal suspensions relies on controlling the crystal size, shape, and polymorphic form. These factors influence how the drug dissolves and is absorbed in the body. Smaller crystals provide a larger surface area relative to their volume, leading to improved dissolution rates and bioavailability, allowing the drug to be gradually released over time rather than all at once. This slow, sustained release significantly reduces initial pain upon administration and extends the therapeutic effect duration.
The discovered method leverages the physical chemistry of crystals and advanced formulation techniques to create extended-release drug systems that minimize pain, enhance convenience, and improve treatment outcomes in various therapeutic areas, such as contraception and chronic disease management. Furthermore, these advancements pave the way for tailored dosing and controlled release through personalized and 3D-printed therapies, addressing individual needs more effectively.
This development could also be applied to health-and-wellness and fitness-and-exercise, offering sustained-release nutrients for optimal well-being. Additionally, the technology used in manufacturing these tiny crystal suspensions could potentially be extended to create tailored, controlled-release fitness supplements, further enhancing overall fitness and wellness.
